How to be a Positive Thinker

How to be a Positive ThinkerHow to be a Positive ThinkerWhether you believe in the Law of Attraction, The Secret, the power of positive thinking, or you think positive thinking is a bunch of new age bologna, few can argue with the fact that people simply are happier and feel more optimistic when they have positive thoughts. For those in sales, positive thinking can lead to more creative thinking which can lead to more closed sales. Knowing how to think positively is as important as wanting to. Here are a few steps to how to be a positive thinker from the business world. Difficulty AverageTime Required A second to start, a lifetime to master Heres How Determine Your Desired Outcome The problem with many people is that they dont know what they want out of life or a particular situation. Take a moment a decide what it is that you want out of a life event. Clear intentions yield clear results while fuzzy desires yield fuzzy results.Make A List of Things You Are Grateful For Tony Robb ins, well-known life coach, and motivational speaker says that no matter how much money you may have in your accounts if you are not grateful, you are poor. Gratitude is an amazing emotion in that it is almost impossible to feel negative thoughts when you are focusing on things you are grateful for.If you make a list of 10 things that you are grateful for every day, you will put yourself in a very positive mindset that will last your entire day. Learn to Count to 5 fruchtwein of us spend our lives reacting to events. How we react is usually governed by how we either learned to react or have reacted to similar events in our past. But simply reacting does not allow any room for creative and targeted thinking,Next time you find yourself in a situation that presents a challenge to your decision to be more positive, hold your reaction and count to 5. This brief break will give you the opportunity to decide how you want to respond, instead of simply reacting. Cut Back on the Nightly News Whichever nightly berichterstattung program you prefer, you probably are aware of how much negative news is reported. Expose yourself to an abundance of negativity and, like it or not, you will begin to be more negative.Negativity is like a drug. The more you expose yourself to negativity and negative people, the more you adopt negativity into your life.Instead, try to surround yourself with positive people and positive exposures. If you absolutely must know whats going on in the world, read the headlines on an Internet news stream and only read those stories that affect your world. Take Care of Yourself The benefits of exercise, a healthy diet and getting enough sleep have been well documented. But just knowing about all the benefits does nothing for you unless you take action.Daily actionSomeone who can exercise but who chooses not to is no better off than someone who cannot exercise. Daily exercise, when coupled with a healthy diet and enough rest can do wonders for your outlook. When you feel good, it takes effort to make yourself feel bad.Track Your Progress As with any goal, the person who you become as you progress towards your goal is more important than accomplishing the goal itself. As you move towards being a positive thinker, expect that you will have as many negative thinking days as you do positive, focused days. But unless you keep track of your progress, you may not even realize that the numbers of days are shifting more towards the positive and away from the negative. What You Need A list of your goalsA journalA commitment to living a more positive-thought based life

7 Human Organs on One Chip

7 Human Organs on One Chip 7 Human Organs on One Chip Scientists in the U.S. and U.K. have recently grown seven miniature menschenwrdig organs and housed them together on a integrierter schaltkreis to create a human-on-a-chip, a whole body biomimetic device. These clusters of assembled cells mimic how organs in the body function, both separately and in tandem.The chip could take the place of animal and tissue testing for drugs in pharmaceutical development, say its creators. It will have to win regulatory approval in each country looking to use it for tests, and it could allow for insights into how organs interact, says Linda Griffith, professor of biological and mechanical engineering at the Massachusetts Institute of Technology.Griffith heads The PhysioMimetics program at MIT, which has collaborated with CN Bio Innovations, a British company that creates live organ-on-a-chip devices. The $26.3-million development program is funded by the Defense Advanced Research Projects Agency.Dr ug companies have a pipeline and were adding to the tools in their pipeline, Griffith says. What were building is adding to the capability to bring parte of a clinical trial further into the lab. So, before your go to (testing with) people, youre actually trying to bring the people into the lab in miniature form and test things on them.Conceptual schematic of a human-on-a-chip, a whole body biomimetic device. Image MITLabs are already using single organs on a chip to test their drugs. The techniques used to make those organs are the same as those used to create the human system, she says.Researchers and companies have previously grown a liver, a lung, and part of the gut on similar chips,but this is first time seven major organs have been combined to create a functioning human micro-system that mimics human physiology, Griffith says.In its final form, the human-on-a-chip will have ten organs liver, gut, heart, kidney, brain, lung, reproductive system, immune system, vascular system, and skin, says Emma Sceats, CN Bio Innovations chief executive officer. For now, it contains a variety of those.The concept follows the lab-on-a-chip devices that scale single or multiple lab processes down to chip-format, and takes that concept into the medical realm.MIT and the English company created the computer-memory-stick-sized chip from a flexible polymer that features microfluidic channels and seven deep wells that host the organ material. The wells are populated with living organ tissue grown from stem cells or collected during surgery and are then are grown on three-dimensional scaffolds that allow the tissues to adopt the natural 3D structures found in the human body, Sceats says.As in the body, the organs on the chip are supplied with oxygen and food via circulating oxygen-rich fluid pumped through the channels.Researchers will be able to monitor the effects of drugs on chip and look to see is a drug is toxic or beneficial for different organs or the system as a whole, Griffith says.Sceats hopes that the multi-organ device can improve treatments for liver diseases. As of now, a liver transplant is the only way to treat the disease and that comes with multiple complications and the need for a donor, she says.The developers have been careful to ensure the chips can be adapted to integrate future technologies, such as advances in stem cell technologies and personalized medicine that populate the chip with the patients own cells to test or create medicine for their own, unique bodily environment, Griffith says.Jean Thilmany is an independent writer.What were building is adding to the capability to bring part of a clinical trial further into the lab. So, before your go to (testing with) people, youre actually trying to bring the people into the lab in miniature form and test things on them.Prof. Linda Griffith, MIT

Kamlakar Rajurkar, 2018 M. Eugene Merchant Manufacturing Medal...

Kamlakar Rajurkar, 2018 M. Eugene Merchant Manufacturing Medal... Kamlakar Rajurkar, 2018 M. Eugene Merchant Manufacturing Medal... Kamlakar Rajurkar, 2018 M. Eugene Merchant Manufacturing Medal of ASME/SMEThe M. Eugene Merchant Manufacturing Medal was established in 1986 by ASME and SME to honor an individual who has played a significant role in improving the productivity and efficiency of the manufacturing operation.Kamlakar Rajurkar, Ph.D., distinguished professor of engineering, and mechanical and materials engineering at the University of NebraskaLincoln, is honored for pioneering contributions to enhance the productivity of nontraditional machining processes used in automobile, aerospace and medical device manufacturing, including electrical discharge machining and electrochemical machining at macro, micro and nanoscales, through extensive research in process modeling and in sensing and control techniques.With Nebraska since 1983, Dr. Rajurkar is founding director of the Center for Nontraditional Manufacturing Research. In addition to serving in various leadership positions in the College of Engineering, he served as program director of Manufacturing Machines and Equipment at the National Science Foundation (1999-2002).Dr. Rajurkar has more than 135 refereed publications, and he has had nearly 125 technically edited papers published in conference proceedings. He has given keynote presentations at many international manufacturing conferences and is co-inventor on a U.S. patent on cryogenically cooled tool machining.An ASME Fellow, Dr. Rajurkar served as vice president (now technical group leader) of Manufacturing (2005-08) and associate editor of the Journal of Manufacturing Science and Engineering (1991-96, 2004-06). He also has organized sessions at symposia and has been a reviewer of ASME journals. In 1995 he received the Blackall Machine Tool and Gage Award.Dr. Rajurkar is also a Fellow of SME and CIRPThe International Academy for Production Engineerin g. Among his other honors are awards for research, teaching and service.Dr. Rajurkar earned three degrees in mechanical engineering his bachelors degree with honors from Jabalpur University in India in 1966 and his masters degree and Ph.D. from Michigan Technological University in Houghton in 1979 and 1982, respectively.Video profile produced and written by Roger Torda and edited by Juan Yepes. The copyright of this program is owned by The American Society of Mechanical Engineers.

Microfluidics Helps Solve the Mysteries of Sickle Cell Disease

Microfluidics Helps Solve the Mysteries of Sickle Cell Disease Microfluidics Helps Solve the Mysteries of Sickle Cell Disease Microfluidics Helps Solve the Mysteries of Sickle Cell DiseaseSickle cell disease (SCD) is a hereditary disorder that affects more than 13 million people around the world. Sufferers of SCD carry a mutated form of hemoglobin that changes their red blood cells into stiff, sickle-shaped cells that slow down the flow of blood, sometimes piling up and blocking blood vessels, resulting in vaso-occlusion events that can cause severe pain, organ damage, and tissue death.For many other diseases, molecular biomarkers are useful as predictive indicators and can guide intervention and treatment. However, no reliable molecular markers exist for SCD. Fortunately, a team of researchers at the University of Minnesotas Living Devices Laboratory has discovered a biophysical marker that holds great promise for helping to determine the severity of sickle cell disease in patients, as well as developing new treatment methods.David K. Wood, assistant professor of biomedical engineering at the University of Minnesota, and collaborator John Higgins, MD at Massachusetts General Hospital in Boston, developed a microfluidic device that can characterize the dynamics of vaso-occlusion by measuring a biophysical parameter that quantifies the tarif of change of the resistance to flow. This can also indicate disease severity and possibly be used to reduce the frequency of vaso-occlusive crises.prototyp red blood cells flowing freely through veins (top). Abnormal, sickled red blood cells blocking blood flow in a blood vessel (bottom). Image Wikimedia CommonsA Microfluidics ApproachThe major challenge of this research was to develop a system that could measure the complex rheological properties of sickle blood as it passes through small blood vessels with decreasing oxygen levels, says Wood.To achieve this, Woods group developed a microfluidic platform that recreates the size scale and pressures seen in the microvasculature in vivo, while simultaneously controlling blood oxygen concentration. Sickle blood flows through a microchannel, roughly the size of an arteriole or venule, under constant pressure drop. The microchannel is diffusively coupled to a gas reservoir in which the oxygen concentration was controlled by a custom-built gas mixer. The oxygen concentration in the gas reservoir was measured in real time using a fiber optic oxygen sensor inserted into the outlet of the gas reservoir, which was under constant flow. This allowed real-time control for many parameters that mimic the physiological conditions that occur during vaso-occlusion, including channel size, blood pressure, and oxygen concentration.To measure blood flow, a high-speed camera captured high frame rate video sequences of flowing blood in real time. Cells in each video frame were identified computationally based on morphologic criteria. Cell locations in subsequent frames were linked to form trajectories using heuristics and machine learning techniques. The researchers defined the velocity at each point in time as the median cell velocity calculated over a 32-frame video captured at higher than 200 frames per second. Using the velocities computed from video tracking and the applied pressures, the effective viscosity was calculated assuming Stokes flow through a rectangular channel.A major innovation in this work is the building of microchips that actually show uswhatsgoing on inside the menschlich body, says Wood.With these devices, blood flowsjust like it does in the human body and we can reproduce the same kind of complications in the chipsthat people with sickle cell disease experience.Promising ResultsAs oxygen concentration in the blood is reduced, blood velocity remains constant until a critical concentration of oxygen is reached. Once the oxygen concentration drops below this threshold, the velocity decreases significantly, and at a lower oxygen th reshold, the blood fully occludes the microchannel. These oxygen thresholds indicate where rheological changes can be expected to begin in the vasculature and where occlusions are most likely to occur. The group also measured the rate of change in viscosity during an in vitro vaso-occlusive event and found that these measurements correlated very well with overall patient disease severity.Just by measuring a sickle cell patients blood in our device, we can tell you how they are doingclinicallyand whether they are at risk for complications, says Wood. The correlation of blood rheology with patient clinical course is completely new. Were not measuring individual molecules. Were actually measuring the fluid mechanical properties of the blood, and we can use those as biomarkers.Woods research findings could be groundbreaking for developing more effective therapeutics for SCD that shift the viscosity-oxygen relationship to significantly reduce the likelihood of occlusion. The oxygen thres holds Wood has identified could also serve as biomarkers for identifying clinical severity, thereby stratifying patient groups and prioritizing experimental treatments.The idea of using micro devices to model human physiology is an exciting, rapidly growing field with huge potential for treating a wide sortiment of health conditions.For the first time, we are starting to truly understandsickle cell disease, says Wood. We are directly measuring the changes in blood flow that occur in the microcirculation, and we are beginning to understand under what conditions patients will be at risk. Based on our biomarker results, one big application is in diagnosis and clinical monitoring. Even moreexciting is that we could use this device in drug development. No assay exists that can predict the efficacy of potential therapies, andthe result is that no broadly effective therapies exist. Hopefully, using our devices, we can shorten the pipeline and help bring some new therapies to market.Mark Cr awford is an independent writer.Learn more atASME 2015 4th Global Congress on NanoEngineering for Medicine and Biology For Further Discussion Using microfluidics to model human physiology is an exciting, rapidly growing field with huge potential for treating a wide range of health conditions.Prof. David K. Wood, University of Minnesota

Whispered Resume Wizard Secrets

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Unusual Facts About Monster Resume Writing Fee Uncovered by the Pros

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